- 6.1 Review statistics concepts: type 1 and type 2 error, significance level Understanding definition of p-value
- 6.2 Understanding GWAS power estimation including: GWAS power estimation for cohort studies, GWAS power estimation for Case-Control studies with an emphasis on how power varies with minor allele count, how type 1 error increases in the case of binary outcomes and rare variants, and case-control imbalance issues
- 6.3 Understand multiple testing problem. Define ways to correct for multiple testing: Bonferroni correction. Define where the “GWAS significant threshold” comes from
Lecture Videos and Learning Checks
Below is an overview of this module. Using the “Next” button below, please watch the required videos and complete the corresponding learning checks to self-assess your comprehension of the key concepts covered. You may also download the videos directly by clicking on the titles. After you have completed the videos and learning checks, please complete the corresponding assignment.