General instructions:
Please complete the following assignment corresponding to Parts 1 & 2 of Effect Modification & Interaction by no later than Monday, [Date] at 11pm SAST/12am EAT.
At the end of the assignment we ask you to please note 1) approximately how much time you spent on the homework and how much time you spent reviewing the materials (videos and learning checks) , 2) what questions, if any, you have from the videos and/or any places you might have gotten stuck in the assignment, and 3) provide your feedback on the this week’s content and materials. Thank you once again for your assistance in completing these additional questions!
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Question 1 of 15
1. Question
The tables below are loosely based on a published paper and represent hypothetical data on the relationship between post-traumatic stress disorder (PTSD) and risk of dementia stratified by sex. Please answer questions 1 to 4 based on the data in the tables.
(Data was generated based on results from: Flatt, J.D., Gilsanz, P., Quesenberry Jr, C.P., Albers, K.B. and Whitmer, R.A., 2018. Post-traumatic stress disorder and risk of dementia among members of a health care delivery system. Alzheimer’s & Dementia, 14(1), pp.28-34. Table 2)
1. Calculate and interpret the incidence rate ratios for the association between PTSD and dementia separately for males and females.
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Question 2 of 15
2. Question
2. Calculate and interpret the incidence rate differences for the association between PTSD and dementia separately for males and females.
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Question 3 of 15
3. Question
3. Do you find evidence of effect measure modification on the multiplicative scale? Explain.
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Question 4 of 15
4. Question
4. Do you find evidence of effect measure modification on the additive scale? Explain.
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Question 5 of 15
5. Question
5. The graph below shows the absolute risk of an outcome in four groups: (1) doubly unexposed (E1=E2=0); (2) exposed to E1 only (E1=1, E2=0); (3) exposed to E2 only (E1=0, E2=1), and (4) doubly exposed (E1=E2=1). Based on the graph, assuming the estimated risks are unbiased, is there evidence for additive interaction? If so, is it positive or negative interaction? Please explain your answer.
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Question 6 of 15
6. Question
The table below shows the results from a study investigating the association between sleep quality, antepartum depression, and suicidal ideation among pregnant women. Based on the adjusted results, answer the following questions:
6. Is there evidence for interaction on the multiplicative scale? If so, in which direction?
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Question 7 of 15
7. Question
7. Is there evidence for interaction on the additive scale? If so, in which direction?
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Question 8 of 15
8. Question
How much time did you spend on this homework?
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Question 9 of 15
9. Question
Please include here any questions from the recorded lectures or homework that you would like to be addressed during the lab session.
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Question 10 of 15
10. Question
Your feedback is important to us. So that we can adequately adjust the lecture materials, please answer the questions below relating to each of this week’s topics:
Part 1: Overview & Effect Modification
Was the amount of information presented too little, just right, or too much?
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Question 11 of 15
11. Question
The lecture’s contents were clearly explained.
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Question 12 of 15
12. Question
How was the pace of the lecture?
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Question 13 of 15
13. Question
Part 2: Interaction Analysis
Was the amount of information presented too little, just right, or too much?
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Question 14 of 15
14. Question
The lecture’s contents were clearly explained.
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Question 15 of 15
15. Question
How was the pace of the lecture?
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