Welcome to the homepage for all content related to Quality-Control for GWAS: Part 2 for the GINGER Program! You may navigate to the individual parts within Quality-Control for GWAS: Part 2 by clicking on the tabs below. There are four parts to this module with corresponding videos and learning checks available as you click each link.
Learning Objectives
- Define population stratification
- Know the types of populations stratification (ancestry differences, differential bias, family relatedness, cryptic relatedness)
- What is Genomic control?
- What are QQ plots?
- Define limitations (more for historical context)Steps for correcting for stratification using PCA
- Provide toy example of an association analysis using ancestry corrected phenotypes and genotypes
- Provide examples of applications
- Define difference between stratification and polygenic effects
- Define intuitions over LDscore regression model
Lecture Videos and Learn Checks
Below is an overview of this module. Please watch the required videos and complete the corresponding learning checks to self-assess your comprehension of the key concepts covered. After you have completed the videos and learning checks, please complete the corresponding assignment.